4-(1H)-Quinolones and 1,2,3,4-tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni.

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dc.careerCiencias Biológicases
dc.category.authoraddeden_US
dc.contributor.authorSáenz Calderón, Fabián Ernesto
dc.contributor.correspondingSáenz Calderón, Fabián Ernesto
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:31:27Z
dc.date.available2023-11-04T21:31:27Z
dc.date.issued2013
dc.dedication.authorTCes
dc.description.abstractMalaria kills approximately 1 million people a year, mainly in sub-Saharan Africa. Essential steps in the life cycle of the parasite are the development of gametocytes, as well as the formation of oocysts and sporozoites, in the Anopheles mosquito vector. Preventing transmission of malaria through the mosquito is necessary for the control of the disease; nevertheless, the vast majority of drugs in use act primarily against the blood stages. The study described herein focuses on the assessment of the transmissionblocking activities of potent antierythrocytic stage agents derived from the 4(1H)-quinolone scaffold. In particular, three 3-alkylor 3-phenyl-4(1H)-quinolones (P4Qs), one 7-(2-phenoxyethoxy)-4(1H)-quinolone (PEQ), and one 1,2,3,4-tetrahydroacridin- 9(10H)-one (THA) were assessed for their transmission-blocking activity against the mosquito stages of the human malaria parasite (Plasmodium falciparum) and the rodent parasite (P. berghei). Results showed that all of the experimental compounds reduced or prevented the exflagellation of male gametocytes and, more importantly, prevented parasite transmission to the mosquito vector. Additionally, treatment with ICI 56,780 reduced the number of sporozoites that reached the Anopheles salivary glands. These findings suggest that 4(1H)-quinolones, which have activity against the blood stages, can also prevent the transmission of Plasmodium to the mosquito and, hence, are potentially important drug candidates to eradicate malaria.en_US
dc.facultyCiencias Exactas y Naturaleses
dc.id.author1706465786
dc.id.type1
dc.identifier.doi10.1128/AAC.00492-13
dc.identifier.issn1098-6596 - 0066-4804
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/4840
dc.identifier.urihttp://aac.asm.org/content/57/12/6187.short
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsSáenz, F.E., La Crue, A. N., Cross, R.M., Maignan, J.R., Udenze, K.O., Manetsch, R., Kyle, D.E.
dc.magazine.pageRange6187-6195
dc.magazine.titleAntimicrobial Agents and Chemotherapyen_US
dc.magazine.volumeChapter57(12)
dc.rightsClosedAccessen
dc.statepublisheden_US
dc.subjectQuinoloneses
dc.subjectTetrahydroacridines
dc.subjectQuinolones
dc.subjectTetrahydroacridin
dc.title4-(1H)-Quinolones and 1,2,3,4-tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni.en_US
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