Healthcare-associated respiratory tract infection and colonization in an intensive care unit caused by Burkholderia cepacia isolated in mouthwash.

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dc.careerMedicinaes
dc.category.authorauxiliaryen_US
dc.contributor.authorZurita Salinas, LucĂ­a Jeannete
dc.contributor.correspondingZurita Salinas, LucĂ­a Jeannete
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:35:47Z
dc.date.available2023-11-04T21:35:47Z
dc.date.issued2014
dc.dedication.authorTPes
dc.description.abstractObjectives: Burkholderia cepacia has been linked to healthcare-associated infections and colonization caused by contamination of alcohol-free mouthwash used in patients undergoing mechanical ventilation. The purpose of our study was to establish the source of a clustering of healthcare- associated B. cepacia isolates in patients on mechanical ventilation in the intensive care unit (ICU). Methods: During April 2012 the Infection Control Committee became concerned when B. cepacia was isolated from tracheal aspirate cultures of three ICU patients. The medical records for the years 2011 and 2012 were reviewed to identify further cases. Cultures of potential reservoirs were done. Isolates from patients and an alcohol-free mouthwash were submitted to multilocus sequence typing (MLST) analysis and antimicrobial resistance testing. Results: Four patients with positive cultures for B. cepacia were identified before the review of the medical records for the years 2011 and 2012. Nine further cases were identified in the review, defined as a patient with pneumonia who had a culture of respiratory secretions that was positive for B. cepacia. Three were cases of infection and 10 were colonizations. All of the isolates from patients (J, K, L, and M) and mouthwash samples (B19, B20, and B21) were genetically identical by MLST analysis. Conclusions: Our findings strongly suggest that alcohol-free mouthwash solution intrinsically contaminated with B. cepacia was the source of these colonizations and infections involving adults in the ICU.en_US
dc.facultyMedicinaes
dc.id.author1703079119
dc.id.type1
dc.identifier.doi10.1016/j.ijid.2014.07.016
dc.identifier.issn1201-9712
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/5457
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1201971214016014
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsZurita, J., Mejia, L., Zapata, S., Trueba, G., Vargas, A.C., Aguirre, S., Falconí­, G.
dc.magazine.pageRange96-99
dc.magazine.titleInternational Journal of Infectious Diseasesen_US
dc.magazine.volumeChapter29
dc.rightsClosedAccessen
dc.statepublisheden_US
dc.subjectBurkholderiaes
dc.subjectCepaciaes
dc.subjectHealthcare - associatedes
dc.subjectInfectionses
dc.subjectMouthwashes
dc.subjectOutbreakes
dc.subjectICUes
dc.subjectBurkholderia
dc.subjectCepacia
dc.subjectHealthcare - associated
dc.subjectInfections
dc.subjectMouthwash
dc.subjectOutbreak
dc.subjectICU
dc.titleHealthcare-associated respiratory tract infection and colonization in an intensive care unit caused by Burkholderia cepacia isolated in mouthwash.en_US
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