Bats, trypanosomes, and triatomines in Ecuador: new insights into the diversity, transmission, and origins of Trypanosoma cruzi and chagas disease

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dc.careerCiencias Biológicases
dc.category.authoraddeden_US
dc.contributor.authorGrijalva Cobo, Mario Javier
dc.contributor.authorOcaña Mayorga, Sofía Beatriz
dc.contributor.authorPinto Báez, Christian Miguel
dc.contributor.authorVillacis Salazar, Anita Gabriela
dc.contributor.correspondingPinto Báez, Christian Miguel
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:38:19Z
dc.date.available2023-11-04T21:38:19Z
dc.date.issued2015-10-14
dc.dedication.authorTCes
dc.description.abstractThe generalist parasite Trypanosoma cruzi has two phylogenetic lineages associated almost exclusively with bats—Trypanosoma cruzi Tcbat and the subspecies T. c. marinkellei. We present new information on the genetic variation, geographic distribution, host associations, and potential vectors of these lineages. We conducted field surveys of bats and triatomines in southern Ecuador, a country endemic for Chagas disease, and screened for trypanosomes by microscopy and PCR. We identified parasites at species and genotype levels through phylogenetic approaches based on 18S ribosomal RNA (18S rRNA) and cytochrome b (cytb) genes and conducted a comparison of nucleotide diversity of the cytb gene. We document for the first time T. cruzi Tcbat and T. c. marinkellei in Ecuador, expanding their distribution in South America to the western side of the Andes. In addition, we found the triatominesCavernicola pilosa and Triatoma dispar sharing shelters with bats. The comparisons of nucleotide diversity revealed a higher diversity for T. c. marinkellei than any of the T. c. cruzigenotypes associated with Chagas disease. Findings from this study increased both the number of host species and known geographical ranges of both parasites and suggest potential vectors for these two trypanosomes associated with bats in rural areas of southern Ecuador. The higher nucleotide diversity of T. c. marinkellei supports a long evolutionary relationship between T. cruzi and bats, implying that bats are the original hosts of this important parasite.en_US
dc.facultyCiencias Exactas y Naturaleses
dc.id.author1708757742
dc.id.author1711850931
dc.id.author1713628111
dc.id.author1706504535
dc.id.type1
dc.identifier.doi10.1371/journal.pone.0139999
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/5670
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0139999
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsPinto, C.M., Ocaña, S., Tapia, E.E., Lobos, S.E., Zurita, A.P., et al.
dc.magazine.pageRange1-13
dc.magazine.titlePlos Oneen_US
dc.magazine.volumeChapter10 (10)
dc.rightsClosedAccessen
dc.statepublisheden_US
dc.subjectMurciélagoses
dc.subjectEnfermedad de chagases
dc.subjectFilogeniaes
dc.subjectMurciélagos
dc.subjectEnfermedad de chagas
dc.subjectFilogenia
dc.titleBats, trypanosomes, and triatomines in Ecuador: new insights into the diversity, transmission, and origins of Trypanosoma cruzi and chagas diseaseen_US
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