Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast.
| dc.career | Ciencias Biológicas | es |
| dc.category.author | added | en_US |
| dc.contributor.author | Costales Cordero, Jaime Alfredo | |
| dc.contributor.author | Grijalva Cobo, Mario Javier | |
| dc.contributor.author | Villacis Salazar, Anita Gabriela | |
| dc.contributor.author | Ocaña Mayorga, Sofía Beatriz | |
| dc.contributor.corresponding | Grijalva Cobo, Mario Javier | |
| dc.country | Ecuador | es |
| dc.date.accessioned | 2023-11-04T21:40:38Z | |
| dc.date.available | 2023-11-04T21:40:38Z | |
| dc.date.issued | 2015 | |
| dc.dedication.author | TC | es |
| dc.description.abstract | tChagas disease is the most important parasitic disease in Latin America. The causative agent, Trypanosomacruzi, displays high genetic diversity and circulates in complex transmission cycles among domestic,peridomestic and sylvatic environments. In Ecuador, Rhodnius ecuadoriensis is known to be the majorvector species implicated in T. cruzi transmission. However, across vast areas of Ecuador, little is knownabout T. cruzi genetic diversity in relation to different parasite transmission scenarios.Fifty-eight T. cruzi stocks from the central Ecuadorian coast, most of them derived from R. ecuadorien-sis, were included in the study. All of them were genotyped as T. cruzi discrete typing unit I (DTU TcI).Analysis of 23 polymorphic microsatellite loci through neighbor joining and discriminant analysis ofprincipal components yielded broadly congruent results and indicate genetic subdivision between syl-vatic and peridomestic transmission cycles. However, both analyses also suggest that any barriers areimperfect and significant gene flow between parasite subpopulations in different habitats exists. Alsoconsistent with moderate partition and residual gene flow between subpopulations, the fixation index(FST) was significant, but of low magnitude. Finally, the lack of private alleles in the domestic/peridomestictransmission cycle suggests the sylvatic strains constitute the ancestral population.The T. cruzi population in the central Ecuadorian coast shows moderate tendency to subdivision accord-ing to transmission cycle. However, connectivity between cycles exists and the sylvatic T. cruzi populationharbored by R. ecuadoriensis vectors appears to constitute a source from which the parasite invades humandomiciles and their surroundings in this region. We discuss the implications these findings have for theplanning, implementation and evaluation of local Chagas disease control interventions. | en_US |
| dc.faculty | Ciencias Exactas y Naturales | es |
| dc.id.author | 1710870252 | |
| dc.id.type | 1 | |
| dc.identifier.doi | 10.1016/j.actatropica.2015.07.017 | |
| dc.identifier.issn | 0001-706X | |
| dc.identifier.uri | https://repositorio.puce.edu.ec/handle/123456789/5833 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.actatropica.2015.07.017 | |
| dc.indexed.database | Scimago Journal Rank | es |
| dc.language.iso | en | |
| dc.list.authors | Costales, J., Jara, M., Llewellyn, M., Messenger, L., Ocaña, S, et al. | |
| dc.magazine.pageRange | 88-93 | |
| dc.magazine.title | Acta Tropica | es |
| dc.magazine.volumeChapter | 151 | |
| dc.rights | ClosedAccess | en |
| dc.state | published | en_US |
| dc.subject | Trypanosoma cruzi | es |
| dc.subject | Rhodnius ecuadoriensis | es |
| dc.subject | Chagas disease | es |
| dc.subject | Microsatelite | es |
| dc.subject | Transmission cycle | es |
| dc.subject | Trypanosoma cruzi | |
| dc.subject | Rhodnius ecuadoriensis | |
| dc.subject | Chagas disease | |
| dc.subject | Microsatelite | |
| dc.subject | Transmission cycle | |
| dc.title | Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast. | en_US |