Colistin-resistant Escherichia coli clinical isolate harbouring the mcr-1 gene in Ecuador
https://repositorio.puce.edu.ec/handle/123456789/5564
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/div-classtitlecolistin-resistant-span-classitalicescherichia-colispan-clinical-isolate-harbouring-the-span-classitalicmcr-1span-gene-in-ecuadordiv/9F87A76D59BF60BB15821B14E0701A2F
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/div-classtitlecolistin-resistant-span-classitalicescherichia-colispan-clinical-isolate-harbouring-the-span-classitalicmcr-1span-gene-in-ecuadordiv/9F87A76D59BF60BB15821B14E0701A2F
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Date
2016-06-22
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Abstract
Colistin resistance mediated by the mcr-1 gene has been reported worldwide, but to date not from the Andean region, South America. We report the first clinical isolate of Escherichia coli harbouring the mcr-1 gene in Ecuador. The strain was isolated from peritoneal fluid from a 14-year-old male with acute appendicitis, and subjected to molecular analysis. The minimum inhibitory concentration of colistin for the strain was 8 mg/ml and it was susceptible to carbapenems but resistant to tigecycline. The strain harboured mcr-1 and blaCTX-M-55 genes and was of sequence type 609. The recognition of an apparently commensal strain of E. coli harbouring mcr-1 serves as an alert to the presence in the region of this recently described resistance mechanism to one of the last line of drugs available for the treatment of multi-resistant Gram-negative infections.
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Escherichia coli, Enzimología, Escherichia coli, Enzimología