Colistin-resistant Escherichia coli clinical isolate harbouring the mcr-1 gene in Ecuador

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dc.careerMedicinaes
dc.category.authorauxiliaryen_US
dc.contributor.authorZurita Salinas, Lucía Jeannete
dc.contributor.correspondingZurita Salinas, Lucía Jeannete
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:36:59Z
dc.date.available2023-11-04T21:36:59Z
dc.date.issued2016-06-22
dc.dedication.authorTPes
dc.description.abstractColistin resistance mediated by the mcr-1 gene has been reported worldwide, but to date not from the Andean region, South America. We report the first clinical isolate of Escherichia coli harbouring the mcr-1 gene in Ecuador. The strain was isolated from peritoneal fluid from a 14-year-old male with acute appendicitis, and subjected to molecular analysis. The minimum inhibitory concentration of colistin for the strain was 8 mg/ml and it was susceptible to carbapenems but resistant to tigecycline. The strain harboured mcr-1 and blaCTX-M-55 genes and was of sequence type 609. The recognition of an apparently commensal strain of E. coli harbouring mcr-1 serves as an alert to the presence in the region of this recently described resistance mechanism to one of the last line of drugs available for the treatment of multi-resistant Gram-negative infections.en_US
dc.facultyMedicinaes
dc.id.author1703079119
dc.id.type1
dc.identifier.doi10.1017/S0950268816001369
dc.identifier.issn1469-4409
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/5564
dc.identifier.urihttps://www.cambridge.org/core/journals/epidemiology-and-infection/article/div-classtitlecolistin-resistant-span-classitalicescherichia-colispan-clinical-isolate-harbouring-the-span-classitalicmcr-1span-gene-in-ecuadordiv/9F87A76D59BF60BB15821B14E0701A2F
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsOrtega, D., Barba, P., Zurita, J.
dc.magazine.titleEpidemiology and Infectionen_US
dc.magazine.volumeChapter144 (4)
dc.rightsClosedAccessen
dc.statepublisheden_US
dc.subjectEscherichia colies
dc.subjectEnzimologíaes
dc.subjectEscherichia coli
dc.subjectEnzimología
dc.titleColistin-resistant Escherichia coli clinical isolate harbouring the mcr-1 gene in Ecuadoren_US
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