Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health»

Simple item page
dc.contributor.authorReytor González , Claudia Leyva
dc.contributor.authorRicardo Sonia , Emilia
dc.contributor.authorSánchez Suárez , Yasniel
dc.contributor.authorBurboa Charis , Vianey Ariadna
dc.contributor.authorJiménez Flores , Emilia
dc.contributor.authorCevallos Fernández , Emilia Luciana
dc.contributor.authorCampuzano Donoso, Martín
dc.contributor.authorSimancas Racines, Daniel Alejandro
dc.contributor.correspondingReytor González , Claudia Leyva
dc.date.accessioned2026-06-29T14:27:04Z
dc.date.available2026-06-29T14:27:04Z
dc.date.issued2026-06-29
dc.date.issued27/11/2025
dc.description.abstractHeavy metal contamination in agricultural soils has emerged as a critical environmental and public health issue associated with increased gastric cancer incidence worldwide. Among the most concerning pollutants are cadmium, arsenic, and lead, which persist in the environment and enter the human body primarily through the soil–plant–food chain. This review integrates environmental, molecular, and epidemiological evidence to explain how these metals alter gastric mucosal biology and promote carcinogenesis. Mechanistically, cadmium, arsenic, and lead trigger oxidative stress, mitochondrial dysfunction, DNA damage, and epigenetic reprogramming, resulting in genomic instability, resistance to programmed cell death, and the transformation of epithelial cells into invasive phenotypes. These molecular disruptions interact with Helicobacter pylori infection, microbial imbalance, chronic inflammation, and hypoxia-driven remodeling of the gastric stroma, all of which enhance angiogenesis and tumor progression. Advanced experimental platforms, such as gastric organoids, immune co-cultures, and humanized animal models, are improving the understanding of these complex interactions. Adopting a One Health perspective reveals the continuity between environmental contamination, agricultural production, and human disease, underscoring the importance of integrative monitoring systems that combine soil and crop analysis with molecular biomarkers in exposed populations. Strengthening this interdisciplinary approach is essential to design preventive strategies, guide remediation policies, and protect human, animals, and environmental health.
dc.id.author1719015636
dc.id.author1723524102
dc.id.author0502274095
dc.identifier.citation" Reytor-González, C.; Leyva Ricardo, S.E.; Sánchez Suárez, Y.;Burboa Charis, V.A.; Jiménez-Flores, E.; Cevallos-Fernández, E.;Campuzano-Donoso, M.; SimancasRacines, D. Heavy Metal Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective. Int. J. Mol. Sci. 2025, 26,11526. https://doi.org/10.3390/ ijms262311526"
dc.identifier.doihttps://doi.org/10.3390/ijms262311526
dc.identifier.issn1422-0067
dc.identifier.urihttps://www.mdpi.com/1422-0067/26/23/11526
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/49172
dc.indexed.databaseScopus
dc.language.isoEnglish
dc.magazine.pageRange1-25
dc.magazine.titleCódigo Científico Revista de Investigación
dc.magazine.volumeChapterV26 NO. 23
dc.statePublished
dc.subjectCadmium
dc.subjectHeavy metals
dc.subjectGastric cancer
dc.subjectArsenic
dc.subjectLead
dc.subjectEnvironmental contamination
dc.subjectOne Health
dc.titleSuelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health»
dc.title.alternativeHeavy metal-contaminated soils and gastric cancer risk: molecular insights and the relevance of a one health perspective
dc.typeArtículo científico
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health».pdf
Size:
808.36 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Artículos científicos