Meiotic sex in Chagas disease parasite Trypanosoma cruzi

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dc.careerEscuela de Ciencias Biológicases
dc.category.authorprincipalen_US
dc.contributor.authorCostales Cordero, Jaime Alfredo
dc.contributor.correspondingCostales Cordero, Jaime Alfredo
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:32:14Z
dc.date.available2023-11-04T21:32:14Z
dc.date.issued2019
dc.dedication.authorTCes
dc.description.abstractGenetic exchange enables parasites to rapidly transform disease phenotypes and exploit new host populations. Trypanosoma cruzi, the parasitic agent of Chagas disease and a public health concern throughout Latin America, has for decades been presumed to exchange genetic material rarely and without classic meiotic sex. We present compelling evidence from 45 genomes sequenced from southern Ecuador that T. cruzi in fact maintains truly sexual, panmictic groups that can occur alongside others that remain highly clonal after past hybridization events. These groups with divergent reproductive strategies appear genetically isolated despite possible co-occurrence in vectors and hosts. We propose biological explanations for the fine-scale disconnectivity we observe and discuss the epidemiological consequences of flexible reproductive modes. Our study reinvigorates the hunt for the site of genetic exchange in the T. cruzi life cycle, provides tools to define the genetic determinants of parasite virulence, and reforms longstanding theory on clonality in trypanosomatid parasites.en_US
dc.facultyCiencias Exactas y Naturaleses
dc.id.author1710870252
dc.id.type1
dc.identifier.doihttps://doi.org/10.1038/s41467-019-11771-z
dc.identifier.issn2041-1723
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/4990
dc.identifier.urihttps://www.nature.com/articles/s41467-019-11771-z
dc.indexed.databaseOtheres
dc.language.isoen
dc.list.authorsSchwabl, P., Imamura, H., Van den Broeck, F., Costales, J., Maiguashca, J., Miles, M. et al.
dc.magazine.pageRange1-14
dc.magazine.titleNature Communicationsen_US
dc.magazine.volumeChapter10
dc.rightsOpenAccessen
dc.statepublisheden_US
dc.subjectGenética animales
dc.subjectEpidemiologíaes
dc.subjectTrypanosomaes
dc.subjectEnfermedad de Chagases
dc.subjectGenética animal
dc.subjectEpidemiología
dc.subjectTrypanosoma
dc.subjectEnfermedad de Chagas
dc.titleMeiotic sex in Chagas disease parasite Trypanosoma cruzien_US
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