Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM)

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dc.careerCiencias Biológicasen_US
dc.category.authoraddeden_US
dc.contributor.authorCostales Cordero, Jaime Alfredo
dc.contributor.correspondingCostales Cordero, Jaime Alfredoen_US
dc.countryEcuadoren_US
dc.date.accessioned2023-11-04T21:47:56Z
dc.date.available2023-11-04T21:47:56Z
dc.date.issued25/08/2015
dc.dedication.authorTCen_US
dc.description.abstractBackground: Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI. Each DTU presents a particular distribution pattern across the Americas, and is loosely associated with different transmission cycles and hosts. Several DTUs are known to circulate in Central America. It has been previously suggested that TcI infection is benign and does not lead to chronic chagasic cardiomyopathy (CCC). Findings: In this study, we genotyped T. cruzi parasites circulating in the blood and from explanted cardiac tissue of an El Salvadorian patient who developed reactivation Chagas disease while on immunosuppressive medications after undergoing heart transplant in the U.S. as treatment for end-stage CCC. Parasite typing was performed through molecular methods (restriction fragment length polymorphism of polymerase reaction chain amplified products, microsatellite typing, maxicircle sequence typing and low-stringency single primer PCR, [LSSP-PCR]) as well as lineage-specific serology. We show that the parasites infecting the patient belong to the TcI DTU exclusively. Our data indicate that the parasites isolated from the patient belong to a genotype frequently associated with human infection throughout the Americas (TcIDOM). Conclusions: Our results constitute compelling evidence in support of TcI DTU’s ability to cause end-stage CCC and help dispel any residual bias that infection with this lineage is benign, pointing to the need for increased surveillance for dissemination of this genotype in endemic regions, the USA and globally.en_US
dc.facultyCiencias Exactas y Naturalesen_US
dc.id.author1710870252en_US
dc.id.type1en_US
dc.identifier.doi10.1186/s13071-015-1039-3en_US
dc.identifier.issn1756-3305
dc.identifier.urihttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-1039-3en_US
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/6213
dc.indexed.databaseScimago Journal Ranken_US
dc.list.authorsCostales, J.A, Kotton, C.N., Zurita, A.C., García, J., Llewellyn, M.S., et al.en_US
dc.magazine.pageRange1-6en_US
dc.magazine.titleParasites & Vectorsen_US
dc.magazine.volumeChapter8 (435)en_US
dc.rightsClosedAccessen_US
dc.statepublisheden_US
dc.subjectEnfermedades tropicalesen_US
dc.subjectTripanosomiasis americanaen_US
dc.subjectSalud públicaen_US
dc.titleChagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM)en_US
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