Electrochemical dopamine sensor using a nanoporous gold microelectrode: a proof-of-concept study for the detection of dopamine release by scanning electrochemical microscopy

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dc.careerEscuela de Ciencias Químicases
dc.category.authorprincipales
dc.contributor.authorEspinoza Montero, Patricio Javier
dc.contributor.correspondingEspinoza Montero, Patricio Javieres
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:30:23Z
dc.date.available2023-11-04T21:30:23Z
dc.date.issued2018
dc.dedication.authorTCes
dc.description.abstractNanoporous gold (NPG) structures were prepared on the surface of a gold microelectrode (Au-μE) by an anodization-reduction method. Cyclic voltammetry and field emission scanning electron microscopy were used to study the electrochemical properties and the morphology of the nanostructured film. Voltammetry showed an improved sensitivity for dopamine (DA) oxidation at this microelectrode when compared to a bare gold microelectrode, with a peak near 0.2 V (vs. Ag/AgCl) at a scan rate of 0.1 V s−1. This is due to the increased surface area and roughness. Square wave voltammetry shows a response that is linear in the 0.1–10 μmol L−1 DA concentration range, with a 30 nmol L-1 detection limit and a sensitivity of 1.18 mA (μmol L−1)−1 cm−2. The sensor is not interfered by ascorbic acid. The reproducibility, repeatability, long-term stability and real sample analysis (spiked urine) were assessed, and acceptable performance was achieved. The “proof-of-concept” detection of dopamine release was demonstrated by using scanning electrochemical microscopy (SECM) with the aim of future applications for single cell analysis.es
dc.facultyCiencias Exactas y Naturaleses
dc.id.author2100381306es
dc.id.type1es
dc.identifier.doihttps://doi.org/10.1007/s00604-018-2898-zes
dc.identifier.issn1436-5073
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007/s00604-018-2898-z.pdfes
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/4476
dc.indexed.databaseScimago Journal Rankes
dc.list.authorsCatota, H., Hernández, L., Selva, J., Sukeri, A., Espinoza, P., Bertotti, M.es
dc.magazine.pageRange1-9es
dc.magazine.titleMicrochim Actaes
dc.magazine.volumeChapter185es
dc.rightsOpenAccesses
dc.statepublishedes
dc.subjectElectroquímicaes
dc.subjectDopaminaes
dc.subjectMicroscopíaes
dc.titleElectrochemical dopamine sensor using a nanoporous gold microelectrode: a proof-of-concept study for the detection of dopamine release by scanning electrochemical microscopyes
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