Fusaric acid induces a notochord malformation in zebrafish via copper chelation

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dc.careerCiencias Biológicases
dc.category.authorprincipalen_US
dc.contributor.authorNarváez Trujillo, Elizabeth Alexandra
dc.contributor.authorPortero Pico, Carolina Elizabeth
dc.contributor.correspondingStrobel, Scott A.
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:38:31Z
dc.date.available2023-11-04T21:38:31Z
dc.date.issued2015-04-26
dc.dedication.authorTCes
dc.description.abstractOver a thousand extracts were tested for phenotypic effects in developing zebrafish embryos to identify bioactive molecules produced by endophytic fungi. One extract isolated from Fusarium sp., a widely distributed fungal genus found in soil and often associated with plants, induced an undulated notochord in developing zebrafish embryos. The active compound was isolated and identified as fusaric acid. Previous literature has shown this phenotype to be associated with copper chelation from the active site of lysyl oxidase, but the ability of fusaric acid to bind copper ions has not been well described. Isothermal titration calorimetry revealed that fusaric acid is a modest copper chelator with a binding constant of 4.4 9 105 M-1. These results shed light on the toxicity of fusaric acid and the potential teratogenic effects of consuming plants infected with Fusarium sp.en_US
dc.facultyCiencias Exactas y Naturaleses
dc.id.author1000620672
dc.id.author1716265309
dc.id.type1
dc.identifier.doi10.1007/s10534-015-9855-7
dc.identifier.issn1572-8773
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/5684
dc.identifier.urihttps://link.springer.com/article/10.1007/s10534-015-9855-7
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsYin, E., Rakhmankulova, M., De Sena, J., Narváez, A., Strobel, S., et al.
dc.magazine.pageRange783-789
dc.magazine.titleBiometalsen_US
dc.magazine.volumeChapter28
dc.rightsClosedAccessen
dc.statepublisheden_US
dc.subjectHongoses
dc.subjectQuelaciónes
dc.subjectÁcido fusáricoes
dc.subjectHongos
dc.subjectQuelación
dc.subjectÁcido fusárico
dc.titleFusaric acid induces a notochord malformation in zebrafish via copper chelationen_US
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