Fatal acute Chagas disease by Trypanosoma cruzi DTU TcI, Ecuador

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dc.careerEscuela de Ciencias Biológicases
dc.category.authorprincipalen_US
dc.contributor.authorCostales Cordero, Jaime Alfredo
dc.contributor.correspondingCostales Cordero, Jaime Alfredo
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:30:35Z
dc.date.available2023-11-04T21:30:35Z
dc.date.issued2020-02
dc.dedication.authorTCes
dc.description.abstractBackground: Chagas disease is caused by the haemoflagellate protozoan Trypanosoma cruzi. Currently, T. cruzi recognizes seven discrete typing units (DTUs): TcI to TcVI and Tcbat. The genetic diversity of T. cruzi is suspected to influence the clinical outcome. Acute clinical manifestations, which include myocarditis and meningoencephalitis, are sometimes fatal; occur most frequently in children and in immunocompromised individuals. Acute disease is often overlooked, leading to a poor prognosis. Case presentation: A 38-year-old man from a subtropical area of the Andes mountains of Ecuador was hospitalized after 3 weeks of evolution with high fever, chills, an enlarged liver, spleen, and lymph nodes, as well as facial edema. ECG changes were also observed. T. cruzi was identified in blood smears, culture and amplification of DNA by PCR. Tests for anti-T. cruzi IgG and IgM and HIV were negative. Molecular typing by restriction fragment length polymorphism (PCR-RFLP) determined the parasite to DTU TcI. In the absence of a timely anti-T. cruzi medication, the patient died. Conclusions: This is a case of severe pathogenicity and the virulence of a DTU TcI strain in an adult patient. The severe acute Chagas disease was probably overlooked due to limited awareness and its low incidence. Our findings suggest that T. cruzi DTU TcI strains circulating in Ecuador are capable of causing fatal acute disease. Early diagnosis and prompt treatment is of paramount importance to avoid fatalities in acute infections.en_US
dc.facultyCiencias Exactas y Naturaleses
dc.id.author1710870252
dc.id.type1
dc.identifier.doihttps://doi.org/10.1186/s12879-020-4851-0
dc.identifier.issn1471-2334
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/4590
dc.identifier.urihttps://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-020-4851-0.pdf
dc.indexed.databaseOtheres
dc.language.isoen
dc.list.authorsCalvopina, M., Segovia, G., Cevallos, W., Vicuña, Y., Costales, J., Guevara, A.
dc.magazine.pageRange1-5
dc.magazine.titleBMC Infectious Diseasesen_US
dc.magazine.volumeChapter20(143)
dc.rightsOpenAccessen
dc.statepublisheden_US
dc.subjectEnfermedad de Chagases
dc.subjectEpidemiologíaes
dc.subjectTrypanosomaes
dc.subjectEnfermedad de Chagas
dc.subjectEpidemiología
dc.subjectTrypanosoma
dc.titleFatal acute Chagas disease by Trypanosoma cruzi DTU TcI, Ecuadoren_US
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