The Role of Organic Small Molecules in Pain Management

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dc.careerEscuela de Ciencias Biológicases
dc.category.authorprincipalen_US
dc.contributor.authorMeneses Olmedo, Lorena Maribel
dc.contributor.correspondingMeneses Olmedo, Lorena Maribel
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:32:35Z
dc.date.available2023-11-04T21:32:35Z
dc.date.issued2021-07-01
dc.dedication.authorTCes
dc.description.abstractIn this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain management will be studied. Then, the mechanism of different types of pain will be assessed, including neuropathic pain, inflammatory pain, and the relationship found between oxidative stress and pain. This will include obtaining insights into the cyclooxygenase action mechanism of nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and etoricoxib and the structural difference between the two cyclooxygenase isoforms leading to a selective inhibition, the action mechanism of pregabalin and its use in chronic neuropathic pain, new theories and studies on the analgesic action mechanism of paracetamol and how changes in its structure can lead to better characteristics of this drug, and cannabinoid action mechanism in managing pain through a cannabinoid receptor mechanism. Finally, an overview of the different approaches science is taking to develop more efficient molecules for pain treatment will be presented. View Full-Texten_US
dc.facultyCiencias Exactas y Naturaleses
dc.id.author1002429411
dc.id.type1
dc.identifier.doihttps://doi.org/10.3390/molecules26134029
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/5050
dc.identifier.urihttps://www.mdpi.com/1420-3049/26/13/4029
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsCuesta, S. y Meneses, L.
dc.magazine.pageRange4029
dc.magazine.titleMDPI Moleculeses
dc.magazine.volumeChapterVolumen 26 Número 13
dc.rightsOpenAccessen
dc.statepublisheden_US
dc.subjectFármacos antiinflamatorioses
dc.subjectQSARes
dc.subjectManejo del dolores
dc.subjectCiclooxigenasaes
dc.subjectFármaco multiobjetivoes
dc.subjectDolor neuropáticoes
dc.subjectFármacos antiinflamatorios
dc.subjectQSAR
dc.subjectManejo del dolor
dc.subjectCiclooxigenasa
dc.subjectFármaco multiobjetivo
dc.subjectDolor neuropático
dc.titleThe Role of Organic Small Molecules in Pain Managementen_US
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