Active surveillance of candidemia in children from latin america: A key requirement for improving disease outcome.

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dc.careerMedicinaes
dc.category.authorauxiliaryen_US
dc.contributor.authorZurita Salinas, Lucía Jeannete
dc.contributor.correspondingSantolaya, María Elena
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:30:28Z
dc.date.available2023-11-04T21:30:28Z
dc.date.issued2014
dc.dedication.authorTPes
dc.description.abstractBackground: Active surveillance is necessary for improving the management and outcomes of patients with candidemia. The aim of this study was to describe the epidemiologic and clinical features of candidemia in pediatric patients in Latin America. Method: Prospective, multicenter, surveillance study of candidemia in a pediatric population from 23 hospitals in 8 Latin America countries between November 2008 and October 2010. Results: Three hundred and two cases of candidemia were reported with a median incidence of 0.81/1000 admissions. Eighty nine (29%) were neonates. The main risk factors were prematurity, intensive care unit (ICU) admission, parenteral nutrition, respiratory disease and mechanical ventilation in neonates and malignancy, neutropenia, neurological disease and previous use of corticosteroids in children. The main species isolated in neonates and children were Candida albicans (43.8% and 35.7%), Candida parapsilosis (27.0% and 26.3%) and Candida tropicalis (14.6% and 14.6%), respectively. The most frequent antifungal therapy used in neonates and children was deoxycholate-amphotericin-B (43.8% and 29.1%) and fluconazole (28.1% and 53.1%). Seventeen neonates (19.1%) and 20 children (9.4%) did not receive antifungal therapy. The 30-day survival rate was 60% in neonates and 72% in children (P = 0.02). Survival was significantly higher in treated than in nontreated neonates (72% vs. 24%; P < 0.001). A multivariate analysis showed that independent predictors for 30-day mortality in children were renal disease (odds ratio: 4.38, 95% confidence interval: 1.92–10.1, P < 0.001) and receipt of corticosteroids (odds ratio: 2.08, 95% confidence interval: 1.04–4.17, P = 0.04). Conclusions: To our knowledge, this is the first prospective, multicenter surveillance study of candidemia in children in Latin America. This epidemiologic information may provide us with methods to improve preventive, diagnostic and therapeutic strategies in our continent.en_US
dc.facultyMedicinaes
dc.id.author1703079119
dc.id.type1
dc.identifier.doi10.1097/INF.0000000000000039
dc.identifier.issn0891-3668
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/4530
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsSantaloya, M.E., Alvarado, T., Queiroz-Telles, F., Colombo, A.L., Zurita, J., et al.
dc.magazine.pageRange40-44
dc.magazine.titlePediatric Infectious Disease Journalen_US
dc.magazine.volumeChapter33 (2)
dc.rightsClosedAccessen
dc.statepublisheden_US
dc.subjectCandidemiaes
dc.subjectChildrenes
dc.subjectLatin Americaes
dc.subjectEpidemiologyes
dc.subjectCandidemia
dc.subjectChildren
dc.subjectLatin America
dc.subjectEpidemiology
dc.titleActive surveillance of candidemia in children from latin america: A key requirement for improving disease outcome.en_US
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