Assessment of the toxic effects of chitosan-coated magnetite nanoparticles on Drosophila melanogaster

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dc.careerEscuela de Ciencias Químicases
dc.category.authorprincipalen_US
dc.contributor.authorJara Negrete, Eliza Nuit
dc.contributor.authorPilaquinga Flores, María Fernanda
dc.contributor.authorVela Peralta, Doris Jimena
dc.contributor.correspondingJara Negrete, Eliza Nuit
dc.countryEcuadores
dc.date.accessioned2023-11-04T21:41:34Z
dc.date.available2023-11-04T21:41:34Z
dc.date.issued2020-09-25
dc.dedication.authorTCes
dc.description.abstractNanoparticles are a cause for concern because of their potential toxic effects on human health and the environment. The aim of this study was to assess the toxic effect of chitosan-coated magnetite nanoparticles (11.00±4.7 nm) on Drosophila melanogaster through the observation of hemolymph composition, DNA damage, larval survival and lifespan of flies. Chitosan-coated magnetite nanoparticles were synthesized by co-precipitation method. Drosophila larvaes and adults were exposed to 500 and 1000 ppm nanoparticles solution. After exposure, each type of larval hemocytes was recognized. Comet assay was performed to detect the DNA damage in the hemocytes. Also, the larval survival and lifespan of exposed flies were observed. Our results showed the toxic effect of the chitosan-coated magnetite nanoparticles through the increment of hemocytes, the emergence of lamellocytes, the presence of apoptotic hemocytes and the DNA damage detected by comet assay. In addition, nanoparticles produce decreasing of larval survival and shortening of the mean and maximum lifespan. The toxic effect the chitosan-coated magnetite nanoparticles is directly associated with 1000 ppm. No DNA damage was observed at 500 ppm.en_US
dc.facultyCiencias de la Educaciónes
dc.id.author1713089389
dc.id.author1715307110
dc.id.author1712651197
dc.id.type1
dc.identifier.doihttps://doi.org/10.3844/ajassp.2020.204.213
dc.identifier.issn1546-9239
dc.identifier.urihttps://repositorio.puce.edu.ec/handle/123456789/5893
dc.identifier.urihttps://thescipub.com/abstract/ajassp.2020.204.213
dc.indexed.databaseScimago Journal Rankes
dc.language.isoen
dc.list.authorsVela, D., Rondal, J., Cárdenas, S., Gutiérrez-Coronado, J., Jara, E., Debut, A. & Pilaquinga, F.
dc.magazine.pageRange204-213
dc.magazine.titleAmerican Journal of Applied Sciencesen_US
dc.magazine.volumeChapter17 (1)
dc.rightsOpenAccessen
dc.statepublisheden_US
dc.subjectNanopartículases
dc.subjectToxicidades
dc.subjectNanopartículas
dc.subjectToxicidad
dc.titleAssessment of the toxic effects of chitosan-coated magnetite nanoparticles on Drosophila melanogasteren_US
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